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Road Signs And Traffic Signals on DNA
The DNA in the cell nuclei of higher organisms is tightly coiled around protein complexes called nucleosomes, which repress gene expression. Researchers from Ludwig-Maximilians-Universitaet in Munich have now developed a model that explains how nucleosomes...
Researchers Advance Understanding of Enzyme That Regulates DNA
Thanks to a single-molecule imaging technique developed by a University of Illinois professor, researchers have revealed the mechanisms of PcrA helicase, an important DNA-regulating enzyme. To prevent unwanted recombination of a damaged or degraded section...
Discovered Gene Causes Kabuki Syndrome
Using a new, rapid and less expensive DNA sequencing strategy, scientists have discovered genetic alterations that account for most cases of Kabuki syndrome, a rare disorder that causes multiple birth defects and mental retardation. Instead of sequencing...
Scientists At UCLA Map All Mammalian Gene Interactions
In one of the first efforts of its kind, UCLA researchers have taken mammalian genome maps, including human maps, one step further by showing not just the order in which genes fall in the genome but which genes actually interact. GD Star Ratingloading...
Large Risk Schizophrenia Marker Revealed
A group of scientists has identified a genetic variant that substantially increases the risk for developing schizophrenia in Ashkenazi Jewish and other populations. The study, published by Cell Press on August 5 in the American Journal of Human Genetics,...
‘Guardian of the Genome’: Protein Helps Prevent Damaged DNA in Yeast
Like a scout that runs ahead to spot signs of damage or danger, a protein in yeast safeguards the yeast cells’ genome during replication — a process vulnerable to errors when DNA is copied — according to new Cornell research. Science...
Red Blood Cells have a Tiny But Effective Protector — MicroRNA
Pediatric researchers have discovered a new biological pathway in which small segments of RNA, called microRNA, help protect red blood cells from injury caused by chemicals called free radicals. The microRNA seems to have only a modest role when red blood...
Ronin Recruits Protein ‘allies’ to Sustain Embryonic Stem Cell Growth
Ronin, crucial to the self-renewal of embryonic stem cells, and a co-regulator called Hcf-1, binds to a small strand of DNA called a hyperconserved enhancer element to control a gene “program” that stimulates growth of the stem cells and may...
